Recombinant human WFS1 protein   

DFNA14; DFNA38; DFNA6; DIDMOAD; WFRS; WFS; Wolfram syndrome 1 (wolframin); Wolfram syndrome; WOLFRAMIN; WFS1_HUMAN.     

濃度：1mg/ ml

來源：Recombinant Human

純度：≥95% SDS-PAGE

表達系統：Escherichia coli

標簽：His tag   

蛋白長度：Full length protein

內毒素水平：<1.000 Eu/µg

純化方法：HPLC

應用：SDS-PAGE，Western blot，ELISA

Biological activity,immunology research

保存：-20℃

保質期：1年

WFS1 is a novel component of Wolfram syndrome, a rare form of juvenile diabetes. WFS1 plays an important role in maintaining homeostasis of the endoplasmic reticulum (ER) in the pancreas. It is normally up-regulated during insulin secretion, whereas inactivation of the protein can cause ER stress. Chronic ER stress is a major involvement in Wolfram syndrome.

產品名稱：Rabbit Anti-WFS1 protein antibody

Rabbit Anti-WFS1 protein 

別名：DFNA14; DFNA38; DFNA6; DIDMOAD; WFRS; WFS; Wolfram syndrome 1 (wolframin); Wolfram syndrome; WOLFRAMIN; WFS1_HUMAN.                

來源：Rabbit

克隆類型：Polyclonal

濃度：1mg/ml

亞型：IgG

反應：Human (predicted: Mouse,Rat,Cow,Dog,Horse)

應用： WB=1:1000-1:2000,Elisa=1:1000-1:2000,IHC-P=1:100-500

       IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500

理論分子量：97kDa

免疫原：KLH conjugated synthetic peptide derived from human WFS1 protein

保存：-20℃
保質期：1年

產品名稱：Anti-WFS1 protein antibody

Mouse Anti-WFS1 protein

別名：DFNA14; DFNA38; DFNA6; DIDMOAD; WFRS; WFS; Wolfram syndrome 1 (wolframin); Wolfram syndrome; WOLFRAMIN; WFS1_HUMAN.                     

來源：Mouse

克隆類型：Monoclonal

濃度：1mg/ml

亞型：IgG

反應：Human

應用：WB=1:1000-1:2000,Elisa=1:1000-1:2000,IHC-P=1:100-500

       IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500

反應:  Human

理論分子量：97kDa

免疫原：KLH conjugated synthetic peptide derived from human WFS1 protein

保存：-20℃
保質期：1年

Wolfram syndrome protein (WFS1) is an 890 amino acid protein that contains a cytoplasmic N-terminal domain, followed by nine-transmembrane domains and a luminal C-terminal domain. WFS1 is predominantly localized to the endoplasmic reticulum (ER) (1) and its expression is induced in response to ER stress, partially through transcriptional activation (2,3). Research studies have shown that mutations in the WFS1 gene lead to Wolfram syndrome, an autosomal recessive neurodegenerative disorder defined by young-onset, non-immune, insulin-dependent diabetes mellitus and progressive optic atrophy (4).